trio is a not-for-profit, full-service oncology cro that leverages a global network of investigators to accelerate the delivery of quality oncology trials.
cancer-associated fibroblasts (cafs) are vital components of prominent cellular components in lower-grade gliomas (lggs) that contribute to lggs
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long-term cancer survivors represent a sizeable portion of the population. plant-based foods may enhance the prevention of cancer-related outcomes in these patients. we aimed to synthesize the current evidence regarding the impact of plant-based ...
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health and wellness centers offering integrative health services (including both conventional and complementary practices) to achieve optimal health and healing.
as i reflect on the past three years of my life, if i were to sum things up in one word, it would be: grateful. incredibly grateful. my journey has been
meet christopher, who was treated at memorial sloan kettering for stomach cancer that spread to his brain.
through the match research program, motivated first-year villanova undergraduates have the opportunity to pursue research in their first spring semester. applicants do not need substantial experience and will serve as research assistants to faculty mentors.
mary frances mcaleer, m.d., ph.d., department of cns - rad onc clinical, division of radiation oncology
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public health management corporation (phmc) is a nonprofit public health institute that builds healthier communities through partnerships with government, foundations, businesses and community-based organizations. it fulfills its mission to improve the health of the community by providing outreach, health promotion, education, research, planning, technical assistance, and direct services.
background cancer is the most prevalent cause of death globally, and radiotherapy is considered the standard of care for most solid tumors, including lung, breast, esophageal, and colorectal cancers and glioblastoma. resistance to radiation can lead to local treatment failure and even cancer recurrence. main body in this review, we have extensively discussed several crucial aspects that cause resistance of cancer to radiation therapy, including radiation-induced dna damage repair, cell cycle arrest, apoptosis escape, abundance of cancer stem cells, modification of cancer cells and their microenvironment, presence of exosomal and non-coding rna, metabolic reprogramming, and ferroptosis. we aim to focus on the molecular mechanisms of cancer radiotherapy resistance in relation to these aspects and to discuss possible targets to improve treatment outcomes. conclusions studying the molecular mechanisms responsible for radiotherapy resistance and its interactions with the tumor environment will help improve cancer responses to radiotherapy. our review provides a foundation to identify and overcome the obstacles to effective radiotherapy.
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julie present koller, psychologist, villanova, pa, 19085, (484) 282-7175, it has been a privilege and continues to be a privilege to provide therapy to such diverse, curious, and brave individuals who seek out treatment for growth, recovery, healing, greater self-awareness, the desire for deeper relationships and intimacy, and change. bearing witness to the pain, resiliency, and bravery of my patients is humbling, challenging, and highly rewarding work. i look forward to meeting you where you are and utilizing a flexible and integrative approach to treatment to help you on your journey to live with more meaning, vitality, and creativity, along with reductions in symptoms and emotional pain.
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lamia p. barakat, phd, is the director of psychosocial services and behavioral oncology research at children’s hospital of philadelphia. she holds the stephen and susan kelly endowed chair in behavioral oncology.
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hif1 and nfkb are two transcription factors very frequently activated in tumors and involved in tumor growth, progression and resistance to chemotherapy. i...
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about biomedicine and the philosophy of the zabrecky institute of biomedicine located in villanova, pa.
background this cross-sectional, nested cohort study assessed female sexual function index (fsfi) scores in postmenopausal women with breast cancer receiving primary chemotherapy. methods the fsfi questionnaire was administered to 24 postmenopausal women one month after diagnosis of breast cancer (post-diagnosis group) and one month after completion of the first cycle of primary anthracyclin-based chemotherapy (post-chemotherapy group). scores were compared to those of 24 healthy postmenopausal women seeking routine gynecological care (control group). all patients were sexually active at the time of enrollment. mean age was 57.29 ± 11.82 years in the breast cancer group and 52.58 ± 7.19 years in the control group. results scores in all domains of the fsfi instrument were significantly lower in the post-diagnosis group than in controls (−41.3%, p < 0.001). a further major reduction in fsfi scores was evident on completion of one cycle of primary chemotherapy (down 46.7% from post-diagnosis scores, p < 0.003), again in all domains. six patients (25%) ceased all sexual relations, in a significant change from baseline (p < 0.001). after one chemotherapy cycle, a further five patients ceased sexual activity, for a total of 11 (45.8%) participants – a borderline significant difference (p = 0.063). conclusion the present study shows that female sexual function as assessed by the fsfi declines significantly at two distinct points in time: upon diagnosis of breast cancer and after administration of systemic chemotherapy.
the majority of patients with ovarian cancer are diagnosed with late-stage disease. these women face cure rates as low as 15% depending on the subtype of ovarian cancer, a statistic that has not changed over the past several decades.
faculty from the fitzpatrick college of nursing are teacher-scholars who seek opportunities to innovate, disseminate their research findings in top journal publications, and mentor students in the research process.
nathan r handley md is a jefferson health clinician dr. handley is director of the integrative cancer recovery program at the marcus institute of integrative health- jefferson health, and assistant professor in the department of integrative medicine and nutritional sciences. he is board-certified in internal medicine, medical oncology, and integrative medicine. dr. handley has expertise in providing comprehensive, innovative assessments and treatment approaches for cancer survivors and others looking to optimize wellness and enhance the healing process.
it is imperative that nurses and other health care professionals not only recognize the disparities in preventive screenings but become part of the solution. early detection and cancer treatment must be accessible for those with disabilities, as it can help save lives.
meet the residents of the orthopedic surgery program. we offer excellent graduate medical education at one of the largest hospital systems in pittsburgh.
research in neuroscience, natural treatments, and more dr. daniel a. monti’s extensive research experience has focused on neuroscience, brain effects of mind-body interventions, brain mechanisms of healing and recovery, and testing natural molecules for therapeutic efficacy in nervous system diseases and cancer. as both a clinical physician and researcher, he…
abstract was not provided for this article.
major philanthropic support has been fundamental to the growth and success of the marcus institute of integrative health.